CEST Imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T

In this prospective clinical study we compared the ability of asymmetry-based amide proton transfer-weighted (APTw) imaging with Lorentzian-fit-based (PeakAreaAPT and MTconst) and relaxation-compensated (MTRRexAPT and MTRRexMT) CEST-MRI of the amide proton transfer (APT) and semisolid magnetization transfer (ssMT) at 3T for the prediction of the overall survival of patients with glioma at the first follow-up after completion of radiotherapy. The APTw (HR=4.66, p<0.001) was more strongly associated with survival compared to the MTRRexAPT (HR=2.44, p=0.056) and MTconst (HR=2.54, p=0.044). The MTRRexMT and PeakAreaAPT did not display any association with survival.