Can APT-weighted CEST MRI provide robust measurement at 3T? A reproducibility study in healthy brain and tumor across sessions and scanners

The goal of this study was to investigate whether APT-weighted CEST imaging can provide reproducible measurements across scan sessions and scanners. Reproducibility of APT-weighted imaging in healthy brain tissue and tumors was evaluated for three CEST metrics: Lorentzian Difference (LD), magnetization transfer ratio asymmetry (MTRasym), and relaxation-compensated inverse magnetization transfer ratio (MTRREX).