In this study, the APT-weighted (APTwasym) and relaxation-compensated CEST-MRI contrasts of 9 postoperative glioma patients, were analyzed for potential regional differences in gray and white matter. The purpose of this analysis was to identify the influence of the location within the brain on CEST contrasts of tumorous and healthy control tissue, respectively. For relaxation-compensated CEST (MTRRex), (i) differences between gray and white matter and also (ii) regional differences with a decreased contrast inside the frontal lobe were found. On the contrary, the APTwasym was found to be independent of (i) location and (ii) comparable for gray and white matter.
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Kroh et al. (2024) studied this question.
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