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The human olfactory network presents technical challenges for functional MRI due to its location in regions of high static susceptibility. We developed a novel multi-echo EPI (ME-EPI) protocol, optimized for olfactory regions, and compared this protocol to a conventional single-echo EPI (1E-EPI). We show that the optimized ME-EPI increases sensitivity to BOLD activation response for olfactory regions and reduces the numbers of subjects required to detect significant group effects.
Zhao et al. (2024) studied this question.