In regions suffering from magnetic susceptibility effects, the use of BOLD optimized echo combination for averaging Single-Shot/Multi-Echo EPI data across echos, leads to voxels with improves signal but reduced BOLD sensitivity. The use of Multi-shot/Multi-Echo EPI can suppress the susceptibility effects allowing BOLD optimized echo averaging that retains BOLD sensitivity.
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Waggoner et al. (2024) studied this question.
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