Sex-specific changes and association in multiparametric MRI measurement at 3T in adult livers

Imaging biomarkers derived from multiparametric MRI have been investigated for the evaluation of diffuse liver disease. We aimed to determine the sex-specific correlation of MRI parameters with age and BMI, and to evaluate the association between multiparametric MRI parameters. 100 study participants without known hepatic disease were prospectively enrolled. 3 T MRI including T1, T2 and T1ρ mapping and proton density fat fraction (PDFF) and R2* maps were acquired. Multiparametric MRI measures have sex-specific age and BMI dependency. Relaxometry mapping indices could be associated with PDFF. PDFF was significant associated with R2* and T1ρ, but not to T1 or T2.