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Shows that pH-weighted APT MRI detects graded tissue acidosis and glycemic severity in a rat stroke model, highlighting its potential to evaluate ischemic tissue and predict outcomes.
The sensitivity of APT MRI in the evaluation of ischemic tissue status was evaluated in stroke rat brains and compared with conventional MRI methods. APT can detect the different levels of tissue acidosis in the ischemic core, penumbra, and oligemia regions. Additionally, APT can also differentiate the severity of tissue acidosis associated with different blood glycemic levels. Our results indicate that APT MRI is a sensitive pH-weighted imaging marker with great potential for the evaluation of the ischemic tissue status and prediction of the stroke outcome.
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Jin et al. (2024) studied this question.
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