Acute Effects of Electronic and Tobacco Cigarette Aerosol Inhalation on Vascular Function Detected at Quantitative MRI

To assess the acute effects of tobacco and electronic cigarette inhalation on vascular function, multiple MRI markers were analyzed in a study targeting peripheral, central and neurovascular beds of healthy young subjects. Smokers and vapers (9 subjects for a total N=15 study visits), ages 22 to 45 years, underwent two MRI scans, with a smoking or vaping challenge in between. Data from smoking/vaping challenges were combined to assess for their pooled effect. Smoking/vaping had significant acute effects on peripheral reactivity, notably on the superficial femoral artery flow-mediated dilation, baseline velocity and superficial femoral vein baseline oxygen saturation, among others.