Imaging magnetization exchange between cerebrospinal fluid and brain parenchyma in humans at 3 T

Imaging mass exchange between cerebrospinal fluid (CSF) and brain parenchyma tissue is promising for enhancing our understanding about the role of CSF in clearance of metabolic waste and contributes to clinical diagnosis of neurological disorders and degeneration. In this study, we evaluated the feasibility of achieving this goal based on the magnetization transfer effect and CSF-selective spin echo contrast at 3 T in human subjects. The results suggested that techniques with low sensitivity to flow and partial volume effect are required for robust clinical application.