Ultrastructural and immunochemical methods of myelin quantification were applied to validate a model-based MRI techniques, macromolecular proton fraction mapping (MPF), during early development in major white matter tracts and cerebral cortex in rabbits. MPF trajectories were in general agreement with levels of myelination by histology and accurately reflected differential rate of development between white matter tracts and cortical regions.
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Drobyshevsky et al. (2024) studied this question.
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