Diagnostic performance of synthetic MRI and reduced filed-of-view DWI-based IVIM on cervical intraepithelial neoplasis

CIN III is currently reckoned as a high-risk precancerous lesion for highly-possible transformation into cervical cancers. To improve low diagnostic efficiency of traditional MRI on precancerous CIN III for its subtle changes at the cellular level, this study built a combination model with MAGiC and IVIM derived parameters. In particular, a combined model with T2 and f values showed good performance on differentiation CIN III from cervical cancer with the sensitivity, specificity and AUC of 0.0.968, 0.839, 956, and it indeed elevated diagnostic performance especially specificity. In our study, alteration of heterogeneity at the cellular level was suspected to occur as cervix gradually progresses to CIN III stage despite no obvious morphological changes on structural images.