We use Blood Oxygen Level Dependent BOLD in combination with controlled hypercapnic stimulus to investigate the relationship between presumed cerebral blood volume changes and CSF flow in the brain. In a group of 11 subjects, we observe strong CSF inflow to the brain as a result of contracting cerebro-vasculature conforming to the Monro-Kellie Doctrine. Our results suggest that changes in arterial blood gases may provide an ‘engine’ through which to potentially enhance the clearance of waste from the brain.
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Bhogal et al. (2024) studied this question.
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