Regionally-resolved oxygen extraction fraction was investigated in an elderly cohort. OEF was obtained from a single 3D mGRE scan using a novel integrated model of QSM phase signal and quantitative blood oxygenation level dependent magnitude signal. Whereas age showed little influence on this metabolic parameter, a pronounced gender effect was observed. A lifestyle index reflecting physical and social activity as well as alcohol and nicotine consumption showed strong correlations with OEF. Venous blood volume fraction and tissue R2*, but not tissue QSM, also reflected lifestyle influence, showing that brain age is more than number of years.
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Oros‐Peusquens et al. (2024) studied this question.
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