Accelerated 3D Multi-Echo Spin-Echo sequence for T2 mapping of mouse brain metastases using a subspace-based reconstruction

T2 mapping is an important biomarker for pre-clinical imaging to characterize the grows of metastasis but suffers from long acquisition time when performed in 3D. Undersampling of the k-space combined to advanced iterative reconstruction using the temporal redondancy of the data along the echo train could be beneficial to reach a reasonable scan time. This works demonstrates that a subspace-based reconstruction for T2 mapping can be used to accelerate a 3D Multi-Echo Spin-Echo acquisition for in-vivo mouse brain metastasis quantification with an acceleration factor up to 10 while keeping an isotropic spatial resolution of 156µm.