Hippocampal subfields atrophy based on automated volumetry analysis in end-stage-renal disease patients

Cognitive impairment is very common in patients with end-stage renal disease (ESRD). Hippocampal atrophy has been proven to be an effective marker for distinguishing the normal population from the cognitively impaired patients. However, there are almost no studies on changes in hippocampal structure, especially the volume of hippocampal subfields, in ESRD patients. In this study, automated volumetry of hippocampal subfields in ESRD patients was performed and compared with healthy controls, and found that ESRD patients have hippocampal subfield atrophy, especially in bilateral fimbria and right hippocampal tail.