C1 chemistry has a central role in efficiently utilizing single-carbon-molecules contributing significantly to sustainability, innovation and economic growth across various sectors. In this study, we present an efficient and rapid method for synthesizing a variety of heteropyrimidones using cyanoacetamide-based multicomponent reaction (MCR) chemistry. By employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolo-pyrimidones in a one-pot process. A single crystal structure has been obtained revealing certain geometrical features.
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Zingiridis et al. (2024) studied this question.
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