Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole

Q: What does this research mean for the field?

N-arylindoles and N-arylbenzo[e]indoles can be synthesized de novo via a Brønsted acid-catalyzed multicomponent reaction using inexpensive starting materials including anilines, 4-hydroxycyclohexanone or 2-tetralone, and 2,2-dimethoxyacetaldehyde. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Muhammad Kamran Farooqi; Shou-Jin Xiao; Zhen Liu; Minghao Li

doi:10.1039/d6ob00598e

January 1, 2025Organic & Biomolecular Chemistry

Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole

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Key Points

This research aims to develop an efficient method for synthesizing N-arylindole and N-arylbenzo[e]indole using readily available starting materials.
Utilized a multicomponent reaction involving anilines, 4-hydroxycyclohexanone or 2-tetralone, and 2,2-dimethoxyacetaldehyde.
Employed brønsted acid catalysis for reaction facilitation.
Successfully synthesized N-arylindole and N-arylbenzo[e]indole with high yields.
Demonstrated the feasibility of using inexpensive starting materials in the synthesis process.

Implication

Explores multicomponent synthesis of heterocyclic compounds, indicating effectiveness of a cost-efficient method.

Abstract

The most preferred heterocyclic indole core was de novo assembled by a multicomponent reaction (MCR) from inexpensive and broadly available anilines, 4-hydroxycyclohexanone or 2-tetralone, and 2,2-dimethoxyacetaldehyde via an acid catalyzed...

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Cite This Study

Farooqi et al. (2025) studied this question.

synapsesocial.com/papers/69f1a08eedf4b468248070ec https://doi.org/10.1039/d6ob00598e

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Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole

Key Points

Implication

Abstract

Discussion

Cite This Study

Brønsted acid catalyzed multicomponent synthesis of N-arylindole and N-arylbenzo[e]indole

Key Points

Implication

Abstract

Discussion

Cite This Study

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