Figure 5 from IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy

Treg instability is induced by OX40/CD137 bispecific agonist (FS120m) and not anti-PD1 treatment. A, Representative plots showing the frequency of IFNγ⁺ cells of CD4⁺ Foxp3⁻ Tconv cells and Foxp3⁺ Tregs in the blood on day 18 after MC38 tumor implantation. B, Quantification and statistical analysis of data shown in A. Data were analyzed by ordinary one-way ANOVA (B) with Tukey correction for multiple comparisons. Bars and error are mean and SEM. *, P ≤ 0.05; ***, P ≤ 0.001; ****, P ≤ 0.0001.