Figure 1 from IFNγ Production by Functionally Reprogrammed Tregs Promotes Antitumor Efficacy of OX40/CD137 Bispecific Agonist Therapy

OX40 and CD137 are highly coexpressed on tumor-associated Tregs. A, Representative plots showing expression of OX40 and CD137 on resting and activated CD4⁺ Tregs, CD4⁺ Tconv cells, and CD8⁺ T cells from the spleens and tumors of mice inoculated with MC38 cells. B and C, Quantification of resting CD44⁻ CD62L⁺ (left) and activated CD44⁺ CD62L⁻ (right) cells within the indicated T-cell populations in the spleen (B) and tumor (C). Data in B and C were analyzed by one-way ANOVA with Tukey correction for multiple comparisons. Bars and error are mean and SEM. ****, P ≤ 0.0001.