The first enantioselective reaction of acyclic α ‐ketiminoesters with thiols has been developed. Good yields and enantioselectivities were obtained using our original cinchona alkaloid amide/zinc(II) catalysts. The obtained products were converted into useful chiral thiazolidines. Based on experimental results and DFT calculation, transition states were proposed to explain the stereoselectivity of the reaction.
No takes yet. Share an insight, caveat, or question.
Iizuka et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: