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May 18, 2026Organic Letters

Enantioselective Addition of Thiols to Pyrazolone Ketimines by Cinchona Alkaloid-Derived C-2′ Amino Organocatalyst

Yakun Wang Xiaoyu Du Xu Kong Siyu Li Yuli Zhang Jinghao Tian Junjie Gong Zichun Hua Yingchao Duan Tao Zhang

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Key Points

The aim is to explore the enantioselective addition of thiols to pyrazolone ketimines using a specific organocatalyst.
Utilized cinchona alkaloid-derived C-2′ amino organocatalysts for asymmetric synthesis.
Examined reaction conditions to optimize yields and enantioselectivity.
Analyzed the outcomes based on chiral materials.
Achieved high enantioselectivity with specific yield percentages.
Performed quantitative analysis demonstrating effective chiral construction.
Indicated significant potential for developing new synthetic methodologies.

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Implication

Demonstrates the efficiency of enantioselective thiol additions in a chiral framework, highlighting new synthetic routes.

Abstract

The asymmetric construction of chiral

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0ea02cbe05d6e3efb5f0b2 https://doi.org/10.1021/acs.orglett.6c01431

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Enantioselective Addition of Thiols to Acyclic Ketiminoesters Using Cinchona Alkaloid Amide/Zinc(II) Catalysts2024 · 2 citations
2Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T‐1Original Research · 2026
3Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T‐1Original Research · 2026
4Primary amine-catalyzed enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones to α,β-unsaturated ketones2024 · 1 citations
5Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α,β-unsaturated ketonesOriginal Research · 2008 · 129 citations

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