Reveals that prenatal dexamethasone exposure programs cardiovascular dysfunction and elevates blood pressure in female rats, suggesting glucocorticoid-driven autonomic impairment.
Autonomic dysfunction is associated with cardiovascular and neurological disease, including hypertension, heart failure, anxiety, and stress-related disorders. Prior studies demonstrated that late gestation exposure to dexamethasone (DEX) resulted in female-biased increases in stress-responsive mean arterial pressure (MAP) and heart rate (HR), suggesting a role for glucocorticoid-mediated programming of autonomic dysfunction. The present study investigated the influence of sympathetic (SYM) or parasympathetic (PS) blockade on cardiovascular function in male and female rat offspring of mothers injected with DEX
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Madhavpeddi et al. (2024) studied this question.
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