We present a case of a 43-year-old man diagnosed with hypothyroidism, autoimmune hepatitis and steroid-induced diabetes, presenting with a panic attack and backache for three months duration. He had a stiff back with right lower limb stiffness and hyperreflexia. He was confirmed to have stiff person syndrome with positive electromyography and the presence of a high titre of glutamic acid decarboxylase (GAD) antibodies. With a background history of autoimmune diseases and stiffness of limbs, it is important to have a high index of suspicion of stiff person syndrome (SPS), not to miss a treatable organic disorder.
No takes yet. Share an insight, caveat, or question.
Dissanayaka et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: