Case report of a patient with anti-GAD positive stiff person syndrome

Stiff-person syndrome is an extremely rare disease, which is an autoimmune process with the formation of antibodies that mainly damage GABAergic neurons and is characterized by the development of symptoms of progressive rigidity and painful muscle spasms. Aim. To evaluate and describe the features of the clinical course of stiff-person syndrome. Materials and methods. The work is based on the examination data of a patient (male, 20 years old), observed from June 2023 to September 2024, the study and analysis of scientific literature devoted to the problem of stiff-person syndrome. Conclusions. As a result of studying this clinical case, we came to the conclusion about the difficulties in diagnosing stiff-person syndrome, associated with low awareness of this disease, polymorphism of clinical manifestations, and a high frequency of comorbid mental disorders.