The increasing trend of Non-Communicable Diseases among young adults may invite multiple public health challenges in the future.

Objective: To compare the burden of communicable and non-communicable diseases (NCDs) in the USA and globally, particularly among 15-45-year-olds. Methods: The imported data from the WHO Mortality Database portal was analyzed by SPSS. Results: The study shows the percentage of deaths from NCDs out of total deaths in the USA in 2010 and 2019 were 86.7% and 86.8% which are higher than global rates of 78.1% and 80.2%. Despite a similar death percentage out of total death, the death rate due to NCDs increased from 601.04/100,000 (2010) to 687.99/100,000 (2019) and 790.29/100,000 (2020) globally; and from 693.60/100,000 (2010) to 753.35/100000 (2019) and 795.78/100000 (2020) in the USA. On the other hand, the death rate from communicable diseases were 56.57/100000, 55.52/100000, and 129.47/100000 globally; and 44.63/100000, 43.20/100000, and 151.99/100000 in the USA in the respective years. Young adults of 15-45 years show a higher NCD death rate in the USA with an increasing trend. Conclusion: The USA has a higher NCDs dependent mortality rate relative to the global mortality rate, particularly among the 15-45 years age group. During the COVID-19 pandemic, the relative increase in the rate of communicable disease death indicates an interplay between communicable and NCDs.