In smokers with computed tomography-based evidence of functional small airway alterations by parametric response mapping, it is possible to demonstrate that the multiple-breath washout-derived Sacin, an index of acinar ventilation heterogeneity, actually does represent the most peripheral airspaces. This is done by verifying on experimental N 2 washout curves of the first breath, N 2 phase-III concavity predicted by the diffusion-convection interdependence model.
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Verbanck et al. (2024) studied this question.
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