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March 17, 2026European Respiratory Journal

Small airways function in children with mild asthma and normal FEV 1

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Authors

FSFlorian SingerMedical University of GrazCAChiara AbbasSYSophie YammineUniversity Hospital of Bern

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Implication

Assessment reveals abnormal small airways function in children with mild asthma, indicating potential underlying disease.

Key Points

  • To evaluate small airways function in children with mild asthma using a single-breath washout technique.
  • Conducted SBW testing during normal tidal breathing
  • Measured double-tracer gas phase III slope (S DTG ) as the primary outcome
  • Performed triplicate SBW and spirometry tests before and after bronchodilation in asthmatic children
  • Acinar ventilation heterogeneity (S DTG ) was significantly increased in children with asthma compared to controls
  • 11 out of 31 asthmatic children showed abnormal S DTG values
  • After bronchodilation, S DTG improved by an average of 36% from baseline

Cite This Study

Singer et al. (2013) studied this question.

synapsesocial.com/papers/69b8f10fdeb47d591b8c5d57https://doi.org/10.1183/13993003/erj.42.suppl_57.1485
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Also Consider

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  1. 1Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry2024
  2. 2Detailed characterization and impact of small airway dysfunction in school-age asthma2024 · 6 citations
  3. 3Detection of bronchodilator effect by spirometry in preschool asthmatic children2011
  4. 4Slow and fast ventilated lung units in adult asthma assessed from N 2 multiple-breath washouts (MBW)2014
  5. 5Bronchodilators in school children with asthma and normal FEV12014