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March 24, 2026European Respiratory Journal

Slow and fast ventilated lung units in adult asthma assessed from N 2 multiple-breath washouts (MBW)

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Authors

SKSanna KjellbergOZO. ZetterströmSkaraborg HospitalMSMaria StrömLund University

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Overview

Demonstrates the utility of N2 MBW for quantifying underventilated lung volumes in asthma, indicating potential for better assessment methods.

Key Points

  • To explore how N2 multiple-breath washouts can measure underventilated lung volumes in adults with asthma.
  • Analyzed 62 asthmatic subjects aged 19-67 using N2 MBW and spirometry.
  • Used semi-log plots of exhaled N2 volume to calculate lung compartments and ventilation.
  • Employed reference values from healthy controls for comparisons.
  • Median slow compartment volume was 54% of functional residual capacity.
  • Specific ventilation for slow and fast compartments were 7.4% and 40.2%, respectively.
  • Inversely correlated slow compartment ventilation with LCI and directly with FEV1/FVC ratio.

Cite This Study

Kjellberg et al. (2014) studied this question.

synapsesocial.com/papers/69c2299aaeb5a845df0d4439https://doi.org/10.1183/13993003/erj.44.suppl_58.p2127
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
  2. 2Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry2024
  3. 3Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  4. 4Small airways function in children with mild asthma and normal FEV <sub>1</sub>2013
  5. 5Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026