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March 18, 2026European Respiratory Journal

Sensitivity of N 2 single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)

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Authors

BHBirgitta HoultzSahlgrenska University HospitalMGMarita GilljamSahlgrenska University HospitalMRMonica RosbergDrottning Silvias barn- och ungdomssjukhus

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Overview

Compares the sensitivity of N2 single breath and multiple breath washout tests in adults with cystic fibrosis, indicating implications for clinical assessments.

Key Points

  • This study aims to evaluate and compare the sensitivity of N2 single breath washout (SBW) and multiple breath washout (MBW) tests in individuals with cystic fibrosis.
  • Conducted spirometry and N2 washout tests in 20 adults with cystic fibrosis and 20 healthy controls.
  • Used the Exhalyzer D device to record triplets of N2 MBW, VC, and FRC+1L SBW tests.
  • Calculated normalized phase III slopes from SBW tests for analysis.
  • LCI and Scond were abnormal in all 20 cystic fibrosis subjects.
  • Sacin was abnormal in 12 out of 20 subjects (p=0.003).
  • VCSn III * Vol,exp was abnormal in 13 out of 20 subjects (p=0.008).
  • FRC+1L Sn III * Vol,exp was abnormal in 18 out of 20 subjects (not significant).
  • FEV1 was abnormal in only 6 subjects (p<0.001).

Cite This Study

Houltz et al. (2013) studied this question.

synapsesocial.com/papers/69ba43764e9516ffd37a4beahttps://doi.org/10.1183/13993003/erj.42.suppl_57.p3605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  2. 2Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026
  3. 3Phase 3 slope indices:can accurate estimates be obtained from 2 tests?2014
  4. 4Prospective longitudinal measurements of N <sub>2</sub> multiple breath washout indices in primary ciliary dyskinesia2014
  5. 5Single and multiple breath nitrogen washout compared with the methacholine test in patients with suspected asthma and normal spirometry2024