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September 10, 2025Journal of Cystic FibrosisOpen Access

Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times?

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Authors

AEAmany F. ElbehairyDBDavid W. BoormanCMCraig W. MacNaughton

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Overview

Analysis evaluates if two repeats of the lung clearance index can replace three, suggesting reduced testing time in cystic fibrosis patients.

Key Points

  • Two lung clearance index tests may offer similar accuracy to three tests in cystic fibrosis patients, minimizing overall testing duration.
  • Patients undergoing testing often face significant time demands; thus, reducing required repeats presents a practical benefit for clinical care.
  • Multiple breath washout testing serves to assess ventilation heterogeneity and monitor treatment effects in cystic fibrosis.
  • This investigation aims to improve clinical practice guidelines and enhance patient experience during lung clearance index assessments.

Cite This Study

Elbehairy et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad6354b1d3bfb60e595chttps://doi.org/10.1016/j.jcf.2025.07.016
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  2. 2Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026
  3. 3Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
  4. 4Heterogeneous use of multiple breath washout in cystic fibrosis across age groups and European countries: an ECFSPR analysis2025 · 1 citations
  5. 5LCI as an endpoint in COPD: Comparison with healthy controls, using SF <sub>6</sub> and nitrogen washout2014