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March 24, 2026European Respiratory Journal

LCI as an endpoint in COPD: Comparison with healthy controls, using SF 6 and nitrogen washout

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Authors

ABAlan BellJDJames DeanDSDave Singh

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Overview

Comparison of lung clearance index in COPD patients and healthy controls indicates its potential as a reliable outcome measure.

Key Points

  • This research evaluates lung clearance index (LCI) for its suitability as an outcome measure in chronic obstructive pulmonary disease (COPD).
  • Conducted multiple breath washout (MBW) using nitrogen and sulfur hexafluoride in COPD patients and healthy controls.
  • Performed tests on the same day in triplicate with both devices.
  • Assessed lung clearance index, functional residual capacity, and test time.
  • Patients with COPD displayed significantly higher LCI values than healthy controls for both nitrogen and SF6 measurements (p<0.0001).
  • Functional residual capacity showed no significant difference between groups for both methods (p=ns).
  • Long testing times were reported for both nitrogen and SF6 systems, averaging around 41 minutes.

Cite This Study

Bell et al. (2014) studied this question.

synapsesocial.com/papers/69c229b2aeb5a845df0d489fhttps://doi.org/10.1183/13993003/erj.44.suppl_58.p1989
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  2. 2Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026
  3. 3Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
  4. 4Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times?2025
  5. 5The reproducibility and responsiveness of the lung clearance index (LCI) in bronchiectasis2014