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March 24, 2026European Respiratory Journal

The reproducibility and responsiveness of the lung clearance index (LCI) in bronchiectasis

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Authors

LGLJF GrilloRoyal Brompton HospitalSIS. IrvingRoyal Brompton HospitalJDJ.C. DaviesRoyal Brompton Hospital

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Implication

Assesses lung clearance index responsiveness in bronchiectasis, revealing limited usefulness for clinical assessment.

Key Points

  • The aim is to evaluate the reproducibility and responsiveness of the lung clearance index in bronchiectasis patients during stable and exacerbating conditions.
  • 25 stable outpatients and 27 exacerbating inpatients assessed for LCI and lung function on two occasions
  • Exacerbating patients tested before and after 10 days of intravenous antibiotics
  • Data analysis conducted using Mann Whitney U and Wilcoxon Signed Rank tests
  • LCI showed high reproducibility (ICC 0.915) in stable patients
  • No significant differences in LCI between stable and exacerbating patients or before and after IV antibiotics
  • FEV1% and FVC% demonstrated significant improvement with IV antibiotics in exacerbating patients

Cite This Study

Grillo et al. (2014) studied this question.

synapsesocial.com/papers/69c229a5aeb5a845df0d4618https://doi.org/10.1183/13993003/erj.44.suppl_58.p2572
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation Between Lung Clearance Index (LCI) and Forced Expiratory Volume (FEV1) in Children with Cystic Fibrosis (CF): A Cross-sectional Study2024 · 1 citations
  2. 2Prospective follow up over 1 year with N 2 multiple breath washout (MBW) in children with cystic fibrosis2013
  3. 3The predictive role of lung clearance index on FEV1 decline in cystic fibrosis2024
  4. 4Lung Clearance Index (LCI) and FEV 1 on the evaluation of the effect of tobramycin solution for inhalation (TIS) among patients with cystic fibrosis2014
  5. 5Lung clearance index- A new parameter for airway obstruction in acute bronchiolitis?2014