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March 24, 2026European Respiratory Journal

Lung Clearance Index (LCI) and FEV 1 on the evaluation of the effect of tobramycin solution for inhalation (TIS) among patients with cystic fibrosis

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Authors

EHElpis HatziagorouVAVasiliki AvramidouAristotle University of ThessalonikiAKAsterios KampourasAristotle University of Thessaloniki

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Implication

Assesses LCI's effectiveness in detecting treatment response to inhaled tobramycin in children with cystic fibrosis, suggesting its usefulness over FEV1.

Key Points

  • The aim is to evaluate the effectiveness of lung clearance index (LCI) in detecting responses to inhaled tobramycin in children with cystic fibrosis.
  • Conducted multiple breath washout and spirometry tests
  • Involved 15 children and adolescents with cystic fibrosis
  • Assessed LCI and FEV1 before and after a four-week course of inhaled tobramycin
  • Compared results post-treatment and after a four-week washout period
  • Mean LCI improved significantly after treatment and worsened after washout (mean change: -1.38, p:0.015)
  • Mean FEV1 showed no significant change post-treatment or after the washout period (p:0.638 and p:0.783)

Cite This Study

Hatziagorou et al. (2014) studied this question.

synapsesocial.com/papers/69c229bdaeb5a845df0d49b8https://doi.org/10.1183/13993003/erj.44.suppl_58.p1222
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lung clearance index (LCI2.5) changes after initiation of Elexacaftor/Tezacaftor/Ivacaftor in children with cystic fibrosis aged between 6 and 11 years: The “real‐world” differs from trial data2024 · 10 citations
  2. 2Correlation Between Lung Clearance Index (LCI) and Forced Expiratory Volume (FEV1) in Children with Cystic Fibrosis (CF): A Cross-sectional Study2024 · 1 citations
  3. 3The reproducibility and responsiveness of the lung clearance index (LCI) in bronchiectasis2014
  4. 4The predictive role of lung clearance index on FEV1 decline in cystic fibrosis2024
  5. 5Lung T1 MRI assessments in children with mild cystic fibrosis lung disease2024 · 3 citations