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March 24, 2026European Respiratory Journal

Lung clearance index- A new parameter for airway obstruction in acute bronchiolitis?

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Authors

PSPatrick StaflerTel Aviv UniversitySWSigal WeinrebHebrew University of JerusalemHMHuda Mussaffi

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Implication

Physiological assessments reveal lung clearance index potential in airway obstruction severity among infants with bronchiolitis, suggesting a need for objective evaluation methods.

Key Points

  • This research examines the feasibility of different lung function tests in diagnosing airway obstruction in infants with acute bronchiolitis.
  • Infants aged 1-12 months with acute bronchiolitis underwent lung function tests.
  • Tests included tidal breathing, exhaled nitric oxide, and multiple breath washout measurements.
  • Comparison was made with healthy controls using facemask and ultrasonic flow meter measurements.
  • Lung clearance index was significantly higher in infants with bronchiolitis (8.4) compared to healthy controls (7.3).
  • Valid tidal breathing measurements were achieved in 66% of AB infants compared to 97% of HC.
  • Exhaled nitric oxide levels were lower in AB infants (2.26 ppb) compared to HC (7.9 ppb).
  • Convalescence showed a slight increase in eNO and a decrease in LCI, but these changes were not statistically significant.

Cite This Study

Stafler et al. (2014) studied this question.

synapsesocial.com/papers/69c229bdaeb5a845df0d4aebhttps://doi.org/10.1183/13993003/erj.44.suppl_58.188
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Also Consider

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  1. 1Multiple-breath washout at 12 months of age reveals lung function impairments in preterm infants with bronchopulmonary dysplasia2026
  2. 2Prospective follow up over 1 year with N 2 multiple breath washout (MBW) in children with cystic fibrosis2013
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  4. 4Pulmonary function testing with tidal breath analyze technique is useful in predicting persistant small airway damage in infants with acute bronchiolitis2020 · 10 citations
  5. 5Multiple-breath washout to detect lung disease in patients with inborn errors of immunity2024 · 4 citations