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March 18, 2026European Respiratory Journal

Prospective follow up over 1 year with N 2 multiple breath washout (MBW) in children with cystic fibrosis

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Authors

ALAnders LindbladMRMonica RosbergBHBirgitta Houltz

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Overview

Prospective evaluation of lung clearance index changes in cystic fibrosis children, indicating stability over one year.

Key Points

  • The aim was to evaluate the changes in lung clearance index over a one-year period in children with cystic fibrosis.
  • Conducted N2 MBW tests in 25 children aged 6-18 years during regular outpatient visits.
  • Recorded triplets of N2 MBW tests using Exhalyzer D in each patient.
  • Included only test occasions with at least two acceptable washouts.
  • A total of 109 N2 MBW test occasions were performed with high technical acceptability.
  • LCI remained stable with no significant difference between initial and final tests.
  • Children with chronic Pseudomonas aeruginosa infection had higher LCI compared to those without.

Cite This Study

Lindblad et al. (2013) studied this question.

synapsesocial.com/papers/69ba434a4e9516ffd37a45d1https://doi.org/10.1183/13993003/erj.42.suppl_57.p3610
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026
  2. 2Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
  3. 3Prospective longitudinal measurements of N <sub>2</sub> multiple breath washout indices in primary ciliary dyskinesia2014
  4. 4Lung clearance index in patients with cystic fibrosis: Can we avoid repeating the test three times?2025
  5. 5Heterogeneous use of multiple breath washout in cystic fibrosis across age groups and European countries: an ECFSPR analysis2025 · 1 citations