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March 24, 2026European Respiratory Journal

Prospective longitudinal measurements of N 2 multiple breath washout indices in primary ciliary dyskinesia

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Authors

HKHelene KobbernagelKGKent GreenAMAstrid Madsen

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Overview

Prospective study assesses variability of nitrogen MBW indices in pediatric primary ciliary dyskinesia, indicating clinical implications for future research.

Key Points

  • To evaluate changes in nitrogen multiple breath washout indices over one year in primary ciliary dyskinesia patients and assess variability.
  • Conducted nitrogen MBW tests in triplets and standard spirometry on three separate occasions over one year.
  • Included 26 patients diagnosed with primary ciliary dyskinesia, aged 6-18 years.
  • Excluded occasions with fewer than two acceptable MBW measurements.
  • Average FEV1 % predicted at baseline was 84.8, indicating variability in lung function.
  • LCI had a within-occasion variability of 6.6%.
  • Scond*VT showed significant improvement throughout the study.
  • Between-occasion CV% for FEV1 was 6.3%, and for LCI was 11.4%, indicating notable variability.

Cite This Study

Kobbernagel et al. (2014) studied this question.

synapsesocial.com/papers/69c2295caeb5a845df0d3b40https://doi.org/10.1183/13993003/erj.44.suppl_58.p4527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  2. 2Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
  3. 3Multiple Breath Washout in Primary Ciliary Dyskinesia: Potential for Lung Disease Monitoring2025 · 1 citations
  4. 4Comparison of spirometry, impulse oscillometry, and multiple breath washout in children with primary ciliary dyskinesia2026
  5. 5Comparing Multiple Breath Washout Parameters in a Matched Cohort of Children With Cystic Fibrosis and Primary Ciliary Dyskinesia2026