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July 29, 2026Pediatric Pulmonology

Comparing Multiple Breath Washout Parameters in a Matched Cohort of Children With Cystic Fibrosis and Primary Ciliary Dyskinesia

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Authors

LVLise VanvuchelenAVAstrid VermautMPMarijke Proesmans

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Overview

Retrospective cross-sectional study compares lung clearance index in matched children with cystic fibrosis and primary ciliary dyskinesia, suggesting impaired detection of lung damage in CF.

Key Points

  • The study aims to compare lung clearance index (LCI) and ventilation parameters between children with cystic fibrosis and primary ciliary dyskinesia.
  • Retrospective cross-sectional design including children aged 6-20 years with available MBW and spirometry data.
  • Participants included matched cohorts of individuals with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) from 2011 to 2024.
  • Key measures included lung clearance index (LCI) and phase III slope parameters.
  • Children with cystic fibrosis exhibited more abnormal LCI values compared to those with primary ciliary dyskinesia (7.8 vs 7.1; p=0.04).
  • FEV1 z-scores were similar between the two groups (−0.1 vs −1.1; p=0.33).
  • A trend towards higher phase III slope parameter S cond x VT in CF participants was observed (0.08 vs 0.06; p=0.11).

Cite This Study

Vanvuchelen et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2bcc8da07d9defa67ffhttps://doi.org/10.1002/ppul.71735
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of spirometry, impulse oscillometry, and multiple breath washout in children with primary ciliary dyskinesia2026
  2. 2Comparison of Spirometry, Impulse Oscillometry, and Lung Clearance Index in Children with Primary Ciliary Dyskinesia2024
  3. 3Multiple Breath Washout in Primary Ciliary Dyskinesia: Potential for Lung Disease Monitoring2025 · 2 citations
  4. 4Prospective follow up over 1 year with N <sub>2</sub> multiple breath washout (MBW) in children with cystic fibrosis2013
  5. 5The Relationship Between Structural and Functional Pulmonary Status and Quality of Life in Children With Primary Ciliary Dyskinesia2026