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March 24, 2026European Respiratory Journal

Phase 3 slope indices:can accurate estimates be obtained from 2 tests?

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Authors

NANoor Ali Al-KhathlanMNManjith NarayananEGErol Gaillard

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Overview

Analysis demonstrates accurate estimates of ventilatory heterogeneity in children using two tests, suggesting practical benefits.

Key Points

  • This research aims to determine if accurate estimates of ventilatory heterogeneity can be obtained from only two multiple-breath washout tests.
  • Analyzed N2 MBW data from 119 school-age children, including 35 with cystic fibrosis (CF).
  • Performed ventilatory assessments in triplicate with a target tidal volume.
  • Compared results from three tests to results from the first two using Bland-Altman plots.
  • No significant difference in ventilatory heterogeneity estimates between two and three tests for the whole population.
  • In CF patients, classifications were concordant in 88.5% of subjects.
  • Differences found in healthy subjects' estimates were not clinically significant.

Cite This Study

Al-Khathlan et al. (2014) studied this question.

synapsesocial.com/papers/69c229b2aeb5a845df0d48dahttps://doi.org/10.1183/13993003/erj.44.suppl_58.p1156
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Also Consider

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  1. 1Sensitivity of N <sub>2</sub> single breath washout (SBW) compared multiple breath washout (MBW) in adults with cystic fibrosis (CF)2013
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  3. 3Measurement of lung clearance index (LCI <sub>2.5</sub> ) by nitrogen multiple breath washout (N <sub>2</sub> -MBW) is feasible and well-tolerated by adults and children with cystic fibrosis2026
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  5. 5Prospective longitudinal measurements of N <sub>2</sub> multiple breath washout indices in primary ciliary dyskinesia2014