Experimental study demonstrates electrochemical deaminative functionalization of primary alkyl amines via alkyl triflimidates, highlighting a general platform for chemical transformations.
Abstract An efficient electrochemical strategy for the deaminative functionalization of alkyl amines has been described. The alkyl triflimidates was readily accessed by the treatment of primary alkyl amines with trifluoromethanesulfonic anhydride and unprecedentedly employed for C − N bond activation. Under cellular conditions or with the promotion of bases, triflimidates can be applied to a range of transformations, including boronation, sulfuration, selenization, sulfonation, oxidation, esterification, and amidation.
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Wang et al. (2024) studied this question.
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