Deaminative Trifluoromethylation of Alkyl Amines Enabled by Photoexcited Copper Complexes

Xian Gong; Hu Du; Yingying Li; Weihang Miao; Shengqing Zhu; Lingling Chu

doi:10.1039/d6qo00659k

January 1, 2026Organic Chemistry Frontiers

Deaminative Trifluoromethylation of Alkyl Amines Enabled by Photoexcited Copper Complexes

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Key Points

The aim is to develop a new method for converting alkyl amines to valuable chemical motifs through trifluoromethylation.
Utilized a photoinduced copper-mediated process
Focused on the direct conversion of alkyl amines
Explored the efficiency of the protocol in chemical synthesis
Successfully achieved deaminative trifluoromethylation of various alkyl amines
Displayed high conversion rates and selectivity for product formation
Demonstrated greater efficiency compared to traditional methods

Implication

Demonstrates a novel method for transforming alkyl amines into valuable compounds, suggesting a breakthrough in chemical synthesis.

Abstract

The direct conversion of abundant alkyl amines to high-value motifs remains highly desirable yet challenging in chemical synthesis. Herein, we disclose a photoinduced copper-mediated protocol for the deaminative trifluoromethylation of...

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Cite This Study

Gong et al. (2026) studied this question.

synapsesocial.com/papers/6a250b707def13d035e1b690 https://doi.org/10.1039/d6qo00659k

View Full Paper

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Deaminative Trifluoromethylation of Alkyl Amines Enabled by Photoexcited Copper Complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

Deaminative Trifluoromethylation of Alkyl Amines Enabled by Photoexcited Copper Complexes

Key Points

Implication

Abstract

Discussion

Cite This Study

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