Recent advances in light-driven synthesis of complex trifluoromethylated aliphatic amines and derivatives

Chi Wai Cheung; Xiaotong Wang; Fuk Yee Kwong

doi:10.1039/d5cc03280f

January 1, 2025Chemical CommunicationsOpen Access

Recent advances in light-driven synthesis of complex trifluoromethylated aliphatic amines and derivatives

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Key Points

Complex trifluoromethylated aliphatic amines enhance metabolic stability and membrane permeability, supporting drug discovery.
New light-driven synthesis techniques yield various derivatives, emphasizing structural complexity.
The study employs innovative methodologies to synthesize compounds, facilitating advancements in pharmaceutical research.
These findings highlight the importance of trifluoromethylated motifs in developing effective drug candidates.

Implication

This research demonstrates new synthesis routes for trifluoromethylated amines, indicating their potential in drug discovery.

Abstract

Trifluoromethylated aliphatic amines, particularly those with structurally complex architectures, have emerged as valuable motifs in drug discovery due to their unique capacity to enhance metabolic stability, membrane permeability, and affinity...

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Cite This Study

Cheung et al. (2025) studied this question.

synapsesocial.com/papers/68a36c360a429f797333076d https://doi.org/10.1039/d5cc03280f

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Recent advances in light-driven synthesis of complex trifluoromethylated aliphatic amines and derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Recent advances in light-driven synthesis of complex trifluoromethylated aliphatic amines and derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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