72232 - Renal and urinary tract malformations among children with esophageal atresia: a single-center retrospective cross-sectional study

Introduction Children with esophageal atresia (EA) may present with concomitant renal or urinary tract malformations, sometimes as part of a VACTERL association. The aim of this study was to map the burden of renal, urinary tract and genital anomalies, impaired kidney function, and micturition difficulties in children with EA, and to investigate the correlation between these anomalies and the type of EA. Method Children presenting with EA at Skåne University Hospital between 2012 and 2023 were identified. Patients deceased within five days of birth were excluded. Data were collected from medical records and included type of EA, concomitant malformations, renal or urinary tract related complications and surgical procedures, and most current serum creatinine. Data were analyzed using Chi2 and Fisher’s exact tests. The study was approved by the Swedish Ethical Review Authority (2010/49). Result 93 patients were included. 18 (19.4%) presented with a renal or urinary tract malformation, most commonly vesicoureteral reflux (n=6). Seven (38.9%) of these patients required surgical intervention. Four (22.2%) and 14 (20.9%) of patients with and without renal or urinary tract malformations had impaired kidney function (p=1.0). Presence of a renal or urinary tract malformation was associated with additional genital anomalies (44.4% and 5.3%, p<0.001) and neurogenic bladder (22.2% and 2.7%, p=0.01). There was no correlation with the type of EA (p=0.62). Discussion The knowledge of concomitant renal and urinary tract malformations and potential complications in children with EA is scarce. This study contributes to the general understanding of comorbidities. Results can help better inform caregivers and direct postnatal care.