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July 31, 2024NatureOpen Access

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions

Pablo Alcón Artur Kaczmarczyk Korak Kumar Ray Themistoklis Liolios Guillaume Guilbaud Tamara Sijacki Y Shen Stephen H. McLaughlin Julian E. Sale Puck Knipscheer David Rueda Lori A. Passmore

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Abstract

DNA crosslinks block DNA replication and are repaired by the Fanconi anaemia pathway. The FANCD2-FANCI (D2-I) protein complex is central to this process as it initiates repair by coordinating DNA incisions around the lesion

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Cite This Study

Alcón et al. (2024) studied this question.

synapsesocial.com/papers/68e5e2c3b6db643587577e40 https://doi.org/10.1038/s41586-024-07770-w

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