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July 31, 2024Open Access

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells

Marianthi Gioulbasani Tarmo Äijö Jair Ernesto Valenzuela Julia Buquera Bettes Ageliki Tsagaratou

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Abstract

DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically, differential gene expression analysis revealed that significant number of genes were upregulated upon TET2 and TET3 loss in iNKT cells. This unexpected finding could be potentially explained if loss of TET proteins was reducing the expression of proteins that suppress gene expression. In this study, we discover that TET2 and TET3 synergistically regulate

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Cite This Study

Gioulbasani et al. (2024) studied this question.

synapsesocial.com/papers/68e5e5bcb6db64358757a56b https://doi.org/10.1101/2024.07.31.605991

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