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A matrix type of transdermal patch formulations having different types of hydrophilic, hydrophobic polymer components Diclofenac potassium (Diclofenac K) served as the model drug and penetration enhancer for topical delivery in this research, employing the USP7 apparatus for dissolution studies. Transdermal patches loaded with Amomum subulatum leaf volatile oil (utilized penetration enhancer) were formulated using the solvent evaporation technique, incorporating varying amounts of pluronic F-127 and ethyl cellulose based on 15 formulations designed by the Box Behnken model. The prepared patches underwent evaluation for various physicochemical parameters, including tensile toughness, moisture content, and moisture uptake. In vitro diffusion studies were conducted using the USP7 apparatus dedicated to transdermal drug release investigations. The optimized formulation, F10, exhibited a drug release of 82% over 24 hours in the in vitro diffusion study. All the transdermal matrix-type formulations demonstrated satisfactory results, indicating that the developed matrix-type transdermal patch, containing different polymers and the A. subulatum leaf volatile oil penetration enhancer, holds potential for transdermal delivery in the treatment of pain and swelling.
Das et al. (Wed,) studied this question.