An Updated Review of Amyloid Beta Oligomer Toxicity Inhibition and Detection for Alzheimer's Disease Diagnosis

Amyloid beta oligomers (AβOs), which are soluble oligomeric state assemblies of amyloid β-protein (Aβ), have been identified as the main pathogenetic factors in the molecular pathology of Alzheimer's disease (AD). Through their disquieting affect on oxidative stress and synaptic disruptions, AβOs exhibit neurotoxicity and synaptotoxicity, and are crucial in the pathological progression of AD. That being said, a number of recent studies have been made impressive strides in characterizing the traits and pathogenicity of Aβos. Reducing the levels of harmful beta-amyloid (Aβ) species by employing small molecules is one possible strategy to stop Alzheimer's disease (AD) from developing. In this review, we examine the mechanisms through which Aβos contribute to the neuropathogenesis that drives the progression of AD. We also have demonstrated the importance of protein aggregation in AD and other neurodegenerative diseases. Additionally we added some traditional chinese medicines and small molecules which can play impressive role into inhibit the progression of amyloid beta oligomers, Lastly we added some Luminescent and NIR fluorescent probes that can detect amyloid beta fib-rills which are the main factor of Alzheimer’s diseases.