Chronic myelomonocytic leukemia (CMML) is an uncommon myeloid neoplasm with myeloproliferative and myelodysplastic features characterized by peripheral monocytosis and cytopenia.1 CMML may have cutaneous manifestations known as leukemia cutis (LC).2 LC in the setting of CMML may portend malignant transformation to acute myeloid leukemia (AML).2 The distribution and morphologic features of LC in CMML are highly variable and often nonspecific.2 CMML may coexist with numerous secondary autoimmune and inflammatory processes; this phenomenon presents a clinical challenge which can delay correct diagnosis and appropriate therapeutic management.
No takes yet. Share an insight, caveat, or question.
Harper et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: