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Introduction: The drugs possessing Vataghna property are much indicated in classics for managing Shotha and Vedana. Cost-effective, widely available, and potent drugs should be encouraged over costly ones. The present study was undertaken based on this, focusing on the bulb of Allium cepa Linn. & Allium ascalonicum Linn. to evaluate the anti-inflammatory and analgesic activities employing carrageenan induced paw oedema in wistar albino rats and hotplate tests in mice, respectively. Materials and Methods: Fresh juice of Allium cepa Linn. and Allium ascaloncum Linn. was given to rats and mice orally to observe anti-inflammatory and analgesic activity, and observed for a day. Anti-inflammatory activity was evaluated using carrageenan induced paw edema model in wistar albino rats. Analgesic activity was evaluated using Hot plate method in mice. Experimental animals were divided into 4 groups, Group A as control was given distilled water and; Group B with standard drug, Paracetamol suspension, Group T 1 as test drug 1 with Swarasa of Allium cepa Linn; and Group T 2 as test drug II with Swarasa of Allium ascalonicum Linn. as per the calculated doses respectively. Results: Animals treated with the test drugs showed a significant reduction in paw oedema and had analgesic effects compared to the control group. The result obtained was also assessed by a one-way-ANOVA test. Discussion: The experiment concludes that both the test drugs have anti-inflammatory and analgesic capabilities. However, anti-inflammatory and analgesic effect was seen better in Allium ascalonicum Linn. than Allium cepa Linn. No adverse effects were noted in the study.
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Jose et al. (2024) studied this question.
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