Recalcitrant lipodermatosclerosis with ulceration treated with oxandrolone and pentoxifylline

Herein we describe the case of a 73-year-old woman with a 15-year history of advanced lipodermatosclerosis with progressive ulceration despite extensive multidisciplinary treatment with compression therapy, surgical venous ablation, topical corticosteroids, antibiotics and hyperbaric oxygen therapy. She was commenced on oxandrolone and pentoxifylline. After 5 months, complete healing of the ulcer was observed without significant adverse effects or hepatotoxicity. Oxandrolone may serve as an effective and safe treatment for ulcerated wounds secondary to advanced lipodermatosclerosis.