What question did this study set out to answer?

To evaluate the efficacy and safety of oxandrolone in reducing surgical burden, improving body composition, and altering clinical outcomes in burn patients.

September 29, 2025SHILAP Revista de lepidopterologíaOpen Access

Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025

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To evaluate the efficacy and safety of oxandrolone in reducing surgical burden, improving body composition, and altering clinical outcomes in burn patients.
Systematic review and updated meta-analysis of randomized controlled trials published between 2005 and 2025 evaluating oxandrolone in burn management.
Oxandrolone significantly decreased surgical burden (SMD = -1.25; p = 0.04), shortened hospital stay normalized to burn size (LOS/TBSA SMD = -1.07; p = 0.007), and improved anabolic recovery through weight gain (SMD = 0.58; p < 0.001) and lean mass acquisition (SMD = 1.30; p < 0.001).
No significant benefits were observed for mortality (RR = 1.04; p = 0.913) or infection incidence (RR = 0.83; p = 0.639).
Adult patients receiving oxandrolone faced a significantly higher incidence of hepatotoxicity compared to controls (19% vs. 5%; p = 0.002), with high heterogeneity observed across studies (I² ≥ 95.0%).

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Implication

Systematic review and meta-analysis reveals oxandrolone aids recovery and shortens hospitalization in burn patients, highlighting metabolic benefits alongside increased hepatotoxicity risk.

Cite This Study

Lou et al. (2025) studied this question.

synapsesocial.com/papers/69d6df9da0177bf533ed93df https://doi.org/10.1186/s13017-025-00648-w

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Implication

Systematic review and meta-analysis reveals oxandrolone aids recovery and shortens hospitalization in burn patients, highlighting metabolic benefits alongside increased hepatotoxicity risk.

Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025

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Discussion

Implication

Cite This Study

Oxandrolone for burn patients: a systematic review and updated meta-analysis of randomized controlled trials from 2005 to 2025

Key Points

Discussion

Implication

Cite This Study

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